This film takes a look at the various ways poisons have been used throughout history, using dramatic reconstructions of some of the most infamous poisonings. But the film doesn't stop there. Using advanced computer animation, we travel inside the bodies of a victim of the Borgias, as well as Cleopatra, Hannibal, Socrates, Emperor Leopold and a host of other unfortunate victims, to witness from the inside how they died. The film follows humanity's macabre search over thousands of years for the perfect poison. A poisoner needs a poison that is tasteless and colorless, and therefore won't be noticed by the victim. It needs to work in low doses, so a poisoner doesn't have to feed his victim large quantities. And it needs to be reliably and quickly lethal. Finally, it needs to be undetectable after the event, so the poisoner leaves no trail of guilt. In fact, for preference it should mimic the symptoms of a disease, so no-one even suspects poisoning. Not surprisingly, such a perfect poison is not easy to find or make, and the search has occupied some of humanity's finest minds.